Nutritional regulation of adiponectin and the effect of genetic variations in the adiponectin gene on bone density in the Newfoundland population

Abstract

Adiponectin, as an adipokine, has been shown to be involved in insulin sensitivity and obesity. Recently data mainly from animal models, have suggested that adiponectin may have a role in bone metabolism. This project addresses the association of adiponectin with insulin sensitivity and obesity status, the regulation of positive energy challenge on adiponectin, and the association of DNA sequence variation in adiponectin gene with bone mineral density in the Newfoundland population. This project comprises two studies: I) a Newfoundland-population based-genetic-association cohort study and 2) an overfeeding study.